Anticholinergic Drug Use And Risk Of Cognitive Decline And Dementia Among Older
  
   Lead Investigator:    Sunil Swami
   Institution      :    University of Florida
   E-Mail           :    drsunil81@ufl.edu
   Proposal ID      :    333


   Publications:


1  Swami S
   Effect of Anticholinergic Exposure on Hippocampal Sclerosis of Aging and Hippocampal Atrophy in Older Adults
   2018   Abstract  The Gerontological Society of America's 70th Annual Scientific Meeting , 

   PRESENTED



2  Swami S, Cohen R, Kairalla JA, Manini TM
   Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment: A Cross-Sectional Analysis
   Journal Article  Drugs Aging,33:809-818,2016,PMC5823249

   PUBLISHED





   Proposal Description:
   Aims: The objectives of the proposed study are to assess the effects of long term AC use on global cognition, specific cognitive domains, and NPs and NFTs deposits in the brain among older adults with PAD. We would assess AC drug load using a valid ordinal Anticholinergic Drug Scale (ADS)  (Level 0, 1, 2, or 3). Cognitive impairment due to continuing AC drug use can be evaluated using meticulous temporal/annual medication records, cognitive and biomarker assessments from the National Alzheimer's Coordinating Center (NACC) database. Therefore, NACC is an excellent resource to address our central hypothesis that older adults with PAD consuming anticholinergic medications are more likely to suffer from early cognitive decline and biomarker burden.    Objective 1: To determine the association between anticholinergic (AC) drug use and global cognitive decline among older adults with PAD.  Hypotheses: Older adults with PAD who are exposed to AC drug use are at higher risk cognitive decline at baseline and progression to MCI/AD over time as compared to older adults not exposed to AC drug use.    Objective 2: To examine the association between AC drug use and domain specific cognitive decline among older adults with PAD.  Hypotheses 2: Older adults with PAD who are exposed to AC drug use are associated with poor response on verbal episodic memory, attention, semantic memory, psychomotor speed/visuospatial function, and executive function tests as compared to older adults not exposed to AC drug use.    Objective 3: To explore the association between AC drug use and neuropathological deposits of NFTs and NPs in postmortem brain of older adults.  Hypotheses 3: Older adults who are exposed to AC drug use are associated with higher deposits of NFTs and NPs in brain as compared to older adults not exposed to AC drug use.